Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect[1].
Molecular Weight:
421.66
CAS Number:
[444914-19-6]
Formula:
C26H47NO3
Target:
Ferroptosis,Glutathione Peroxidase,MDM-2/p53
Application Notes:
MCE Product type: Natural Products
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