L67 (DNA Ligase Inhibitor) is a competitive DNA ligase inhibitor that effectively inhibits DNA ligases I/III (both IC50 are 10 µM). L67 can cause nuclear DNA damage by reducing levels of mitochondrial DNA and increasing levels of mitochondrially-generated ROS. L67 also activates the Caspase 1-dependent apoptosis pathway in cancer cells, can be used in cancer research[1][2].
Molecular Weight:
486.11
Purity:
98
CAS Number:
[325970-71-6]
Formula:
C16H14Br2N4O4
Target:
Apoptosis,Caspase,DNA/RNA Synthesis,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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