GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 shows ~100-fold selectivity for GPR40 over GPR120. GW9508 is inactive against other GPCRs, kinases, proteases, integrins and PPARs. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener. Anti-inflammatory and anti-atherosclerotic activities[1][2][3][4].
Molecular Weight:
347.41
Purity:
99.23
CAS Number:
[885101-89-3]
Formula:
C22H21NO3
Target:
Free Fatty Acid Receptor,Potassium Channel
Application Notes:
MCE Product type: Reference compound1
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