GM-90257 is a microtubule acetylation inhibitor. GM-90257 binds directly to alpha-tubulin. GM-90257 prevents the recruitment of alpha-tubulin acetyltransferase 1 (alphaTAT1) to the K40 residue in alpha-tubulin. GM-90257 causes Apoptosis, downregulates BCl-2, and activates JNK and PARP. GM-90257 has anticancer activity against breast cancer[1][2].