SSE1806 is a derivative of podophyllotoxin (a natural antimitotic agent) and a microtubule/tubulin inhibitor with significant anticancer and antiproliferative activities. The GI50 of SSE1806 on cancer cell growth ranges from 1.29-21.15 µM. SSE1806 causes mitotic abnormalities and G2/M phase arrest, increases p53 expression, and inhibits colon cancer organoid growth. SSE1806 is able to overcome multidrug resistance in cell lines overexpressing MDR-1[1].
Molecular Weight:
378.38
CAS Number:
[3053861-26-7]
Formula:
C21H18N2O5
Target:
Apoptosis,Microtubule/Tubulin,Mitosis
Application Notes:
MCE Product type: Reference compound
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