Loperamide (ADL 2-1294) is selective and orally active µ opioid receptor agonist with Ki valuess of 3, 48 and 1156 nM against µ, delta and kappa opioid receptor, respectively. Loperamide produces antinociception and antihyperalgesia. Loperamide exhibits peripheral selectivity, enhancing fluid, electrolyte, and glucose absorption, reversing PGE2 (HY-101952)- and Cholera toxin (HY-P1446)-induced intestinal secretion, and reducing intestinal motility. Loperamide can be used for the researches of inflammatory pain and protracted diarrhoea[1][2].
Molecular Weight:
477.04
Purity:
99.85
CAS Number:
[53179-11-6]
Formula:
C29H33ClN2O2
Target:
Opioid Receptor
Application Notes:
MCE Product type: Reference compound
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