JNK-IN-14 is a potent JNK inhibitor with IC50 values of 1.81, 12.7 and 10.5 nM for JNK1, JNK2 and JNK3, respectively. JNK-IN-14 induces early-stage apoptosis. JNK-IN-14 shows cell population arrest at the G2/M phase and slightly inhibits beclin-1 production at K562 leukemia cells relative to SP600125 (HY-12041), showing higher inhibitory ability.[1]
Molecular Weight:
521.63
CAS Number:
[2991432-56-3]
Formula:
C27H31N5O4S
Target:
Cytochrome P450,JNK
Application Notes:
MCE Product type: Reference compound1
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