PF-07202954 is an orally active, highly selective DGAT2 inhibitor with an IC50 of 10 nM against human DGAT2 and an IC50 of 17 nM against rat DGAT2. PF-07202954 reduces triglyceride synthesis, decreases hepatic triglyceride content and plasma triglyceride levels, inhibits de novo lipogenesis, and suppresses the hepatic SREBP signaling pathway as well as the expression of SREBP target genes. PF-07202954 is applicable to research related to non-alcoholic steatohepatitis[1].
Molecular Weight:
438.45
Purity:
98.82
CAS Number:
[2639372-47-5]
Formula:
C22H23FN6O3
Target:
Acyltransferase
Application Notes:
MCE Product type: Reference compound
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