VU6004909 is a blood-brain barrier penetrated mGlu1 positive allosteric modulator (PAM), with the EC50s of 25.7 nM and 31 nM for human mGlu1 and rat mGlu1, respectively. VU6004909 reduces dorsolateral striatal dopamine (DA) release in vivo and displays antipsychotic efficacy[1][2][3].
Molecular Weight:
378.35
Purity:
99.40
CAS Number:
[1860797-76-7]
Formula:
C21H15FN2O4
Target:
mGluR
Application Notes:
Reference compound
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