D359-0396 is an orally active NLRP3 inflammasome inhibitor. D359-0396 inhibits pyroptosis and IL-1beta release in macrophages. D359-0396 also inhibits the oligomerization of NLRP3, ASC and the cleavage of GSDMD. D359-0396 alleviates EAE, and also improves survival after septic shock in mice[1].
Molecular Weight:
400.47
Purity:
99.98
CAS Number:
[1031977-31-7]
Formula:
C24H24N4O2
Target:
NOD-like Receptor (NLR),Pyroptosis
Application Notes:
MCE Product type: Reference compound
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