GSK-J4 (hydrochloride) (Standard) is the analytical standard of GSK-J4 (hydrochloride). This product is intended for research and analytical applications. GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 µM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-alpha production in human primary macrophages with an IC50 of 9 µM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1[1][2][3].
Molecular Weight:
453.96
CAS Number:
[1797983-09-5]
Formula:
C24H28ClN5O2
Target:
Histone Demethylase,Reference Standards
Application Notes:
MCE Product type: Reference Standards
* VAT and and shipping costs not included. Errors and price changes excepted
