SGC0946 is a selective DOT1L inhibitor with an IC50 value of 0.3 nM. By inhibiting DOT1L, SGC0946 can induce G1 phase arrest, suppress cell self-renewal and metastatic potential, and induce cell differentiation in cancer cells. SGC0946 can be used in the research of tumors such as leukemia and breast cancer, and also serves as a probe to further investigate the cellular mechanisms of DOT1L in normal and diseased cells[1][2][3].
Molecular Weight:
618.57
Purity:
99.68
CAS Number:
[1561178-17-3]
Formula:
C28H40BrN7O4
Target:
Histone Methyltransferase
Application Notes:
MCE Product type: Reference compound1
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