S3226 is a highly selective NHE-3 inhibitor (IC50NHE-3-mediated sodium transport. S3226 significantly inhibits blastocyst formation and expansion in mouse embryos, and reduces fluid and electrolyte reabsorption in rat proximal tubules in a dose-dependent manner. S3226 effectively alleviates ischemia-induced acute renal failure by improving renal function parameters, reducing renal tubular injury and restoring intracellular pH homeostasis, without interfering with the normal tubuloglomerular feedback response. S3226 is widely used in studies of acute renal failure and related pathological mechanisms[1][2][3].
Molecular Weight:
415.32
Purity:
99.65
CAS Number:
[215183-03-2]
Formula:
C17H24Cl2N6O2
Target:
Na+/H+ Exchanger (NHE)
Application Notes:
MCE Product type: Reference compound
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