GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose). GKA50 stimulates insulin release from mouse islets of Langerhans. GKA50 is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca2+-dependent modulator of insulin secretion. GKA50 shows significant glucose lowering in high fat fed female rats[1][2][3][4].
Molecular Weight:
464.51
Purity:
99.84
CAS Number:
[851884-87-2]
Formula:
C26H28N2O6
Target:
Glucokinase
Application Notes:
MCE Product type: Reference compound
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