GKA50 quarterhydrate is a potent glucokinase activator (EC50=33 nM at 5 mM glucose) and stimulates insulin release from mouse islets of Langerhans. GKA50 quarterhydrate is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca2+-dependent modulator of insulin secretion. GKA50 quarterhydrate shows significant glucose lowering in high fat fed female rats[1][2][3][4].
Molecular Weight:
469.01
Purity:
98
Formula:
C26H28N2O6.1/4H2O
Target:
Glucokinase
Application Notes:
MCE Product type: Reference compound
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