KT-333 is a molecular glues that degrades STAT3 protein. KT-333 mediates the selective degradation of STAT3 through the ubiquitin-proteasome system by binding to STAT3 protein and E3 ubiquitin ligase von Hippel-Lindau protein (VHL). KT-333 has strong selectivity for STAT3 protein degradation and good antitumor activity. KT-333 can be used in the study of hematologic malignancies such as large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL)[1].
Molecular Weight:
1257.78
Purity:
97.43
CAS Number:
[2502186-79-8]
Formula:
C60H74ClN10O14PS
Target:
Molecular Glues,STAT
Application Notes:
MCE Product type: Reference compound
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