ATX968 (example 31) is an orally active, potent and selective inhibitor of ATP-dependent RNA helicase A (DHX9), with the EC50 of 0.054 µM in circBRIP1. ATX968 results in robust and durable tumor growth inhibition or regression in mouse xenograft studies with MSI-H/dMMR colorectal cancer cell lines[1][2][3].
Molecular Weight:
421.92
Purity:
99.61
CAS Number:
[2973395-71-8]
Formula:
C18H16ClN3O3S2
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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