LY 367265 is a 5-hydroxytryptamine transporter (SERT) inhibitor (IC50 = 3.1 nM) and a 5-HT2A receptor antagonist (K = 0.81 nM). LY 367265 has the inhibitory activity on the norepinephrine transporter (NET) of extremely weak (IC50 > 1000 nM), it has low affinity for subtypes such as 5-HT1B (K = 490 nM) and 5-HT1D (K = 81 nM), showing high selectivity. LY 367265 concentration-dependently enhances of [H]5-HT efflux (EC50 = 250 nM). LY 367265 antagonizes the contraction response of Sumatriptan (HY-B0121B), indicating its functional antagonistic activity on 5-HT1D-like receptors. LY 367265 can be used for the study of diseases such as anxiety disorders and post-traumatic stress disorder[1].
Molecular Weight:
452.54
CAS Number:
[210751-39-6]
Formula:
C24H25FN4O2S
Target:
5-HT Receptor,Serotonin Transporter
Application Notes:
MCE Product type: Reference compound
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