MTX-216 is a dual ATP-competitive inhibitor of PI3K and EGFR. MTX-216 cosuppresses Ki-67 and ribosomal S6 phosphorylation and induces apoptosis in NF1LOF cells. MTX-216 suppresses the activity of SYK kinase, with an IC50 of 281 nM. MTX-216 is used in the research of Melanoma[1].
Molecular Weight:
502.35
CAS Number:
[1952236-19-9]
Formula:
C22H14Cl2FN5O2S
Target:
Apoptosis,EGFR,PI3K,Syk
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted