Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC50 of 71.8 nM[1]. Epacadostat can effectively reduce Trp metabolism, entailing increased activation and maturation of dendritic cells, and enhanced proliferation of effector T cells and natural killer cells (NKs), as well as attenuated Tregs expansion.
Molecular Weight:
438.23
Purity:
99.65
CAS Number:
[1204669-58-8]
Formula:
C11H13BrFN7O4S
Target:
Indoleamine 2,3-Dioxygenase (IDO)
Application Notes:
MCE Product type: Reference compound
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