UNC3474 is a small molecule ligand, binding with 53BP1. UNC3474 binds the aromatic methyl-lysine binding cage of 53BP1TT, with a dissociation constant (Kd) of 1.0 0.3 µM. UNC3474 inhibits the recruitment of 53BP1 to DSBs by stabilizing a pre-existing autoinhibited state of 53BP1 in cells[1].
Molecular Weight:
276.42
Purity:
98.56
CAS Number:
[1648707-79-2]
Formula:
C17H28N2O
Target:
MDM-2/p53
Application Notes:
MCE Product type: Reference compound
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