CRT0066101 dihydrochloride is a potent and orally active PKD inhibitor with IC50 values of 1 nM, 2.5 nM and 2 nM for PKD1, PKD2, and PKD3, respectively[1]. CRT0066101 dihydrochloride is also a potent PIM2 inhibitor with an IC50 of ~135.7 nM. CRT0066101 dihydrochloride exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects[1][2][3].
Molecular Weight:
411.33
Purity:
99.92
CAS Number:
[1883545-60-5]
Formula:
C18H24Cl2N6O
Target:
Apoptosis,Pim,PKD
Application Notes:
MCE Product type: Reference compound
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