QNZ46 is a highly selective noncompetitive NMDA receptor antagonist targeting GluN2C/D (IC50=3.9 µM), GluN1/GluN2C (IC50=7.1 µM), and GluN1/GluN2D (IC50=182 µM) subunits. QNZ46 inhibits glutamate-mediated calcium influx, thereby blocking excitotoxicity. QNZ46 is membrane permeable and can cross the blood-brain barrier, where it inhibits myelin damage and axonal degeneration[1][2][3].
Molecular Weight:
443.41
Purity:
99.46
CAS Number:
[1237744-13-6]
Formula:
C24H17N3O6
Target:
iGluR
Application Notes:
MCE Product type: Reference compound
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