C105SR is a cyclophilin D (CypD) inhibitor targeting to peptidyl-prolylcis-trans isomerase (PPIase). C105SR inhibits mitochondrial permeability transition opening (mPTP) with an IC 50 of 5 nM. C105SR inhibits hypoxia and reoxygenation inudced hepatocyte apoptosis and increases the level of calcium retention capacity (CRC). C105SR exhibits hepaprotective effect in ischaemia-reperfusion injury (IRI) mouse model[1].
Molecular Weight:
633.60
Purity:
99.49
Formula:
C32H33BrN4O3S
Target:
Apoptosis,Caspase,Cyclophilin
Application Notes:
MCE Product type: Reference compound
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