UNC8153 TFA is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a Kd of 24 nM. UNC8153 TFA reduces the cellular levels of both NSD2 protein (DC50 in cell U2OS is 0.35 µM) and the H3K36me2 chromatin mark. UNC8153 TFA contains a simple warhead that confers proteasome-dependent degradation of NSD2[1].
Molecular Weight:
697.70
Purity:
99.92
CAS Number:
[2929304-61-8]
Formula:
C35H38F3N5O7
Target:
Histone Methyltransferase
Application Notes:
MCE Product type: Reference compound
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