UNC8153 is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a Kd of 24 nM. UNC8153 reduces the cellular levels of both NSD2 protein (DC50 in cell U2OS is 0.35 µM) and the H3K36me2 chromatin mark. UNC8153 contains a simple warhead that confers proteasome-dependent degradation of NSD2[1].
Molecular Weight:
583.68
Purity:
99.13
CAS Number:
[2929304-60-7]
Formula:
C33H37N5O5
Target:
Histone Methyltransferase
Application Notes:
MCE Product type: Reference compound1
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