JAB-2485 is an orally active and selective Aurora kinase A (AURKA) inhibitor with an IC50 value of 0.327 nM. JAB-2485 exhibits inhibitory activity against various tumor cell lines such as neuroblastoma, triple-negative breast cancer, small cell lung cancer, and epithelial ovarian cancer. JAB-2485 can induce cell cycle arrest and apoptosis in tumor cells. JAB-2485 has antitumor activity[1][2].
Molecular Weight:
503.97
Purity:
98.11
CAS Number:
[2899209-55-1]
Formula:
C25H28ClF2N5O2
Target:
Apoptosis,Aurora Kinase,Caspase
Application Notes:
MCE Product type: Reference compound
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