Nampt activator-4 is a NAMPT activator with a human EC50 of 0.058 µM and human Ka of 0.08538 µM, and has an oral bioavailable HCl salt form.Nampt activator-4 binds to the rear channel of NAMPT, increasing enzyme activity by alleviating feedback inhibition by nicotinamide and NAD+.Nampt activator-4 elevates cellular nicotinamide adenine dinucleotide levels.Nampt activator-4 shifts the concentration-response curve of a NAMPT inhibitor to the right by competing for binding to the NAMPT rear channel.Nampt activator-4 demonstrates modest stability in human and mouse liver microsomes.Nampt activator-4 exhibits low to moderate cytochrome P450 inhibition (CYP2D6 >25 µM, CYP3A4 = 13.6 µM).Nampt activator-4 can be used for the research of type-2 diabetes[1].
Molecular Weight:
537.56
Purity:
98.87
CAS Number:
[2847156-05-0]
Formula:
C26H22F3N7OS
Target:
NAMPT
Application Notes:
MCE Product type: Reference compound
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