Tirabrutinib (ONO-4059) hydrochloride is an orally active Brutons Tyrosine Kinase (BTK) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM. Tirabrutinib hydrochloride irreversibly and covalently binds to BTK and inhibits aberrant B cell receptor signaling. Tirabrutinib hydrochloride can be used in studies of autoimmune diseases and hematological malignancies[1][2][3][4].
Molecular Weight:
490.94
Purity:
99.66
CAS Number:
[1439901-97-9]
Formula:
C25H23ClN6O3
Target:
Apoptosis,Btk
Application Notes:
MCE Product type: Reference compound
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