ZX703 (compound 5I) is a PROTAC that significantly degrades GPX4 in a dose- and time-dependent manner through the ubiquitin-proteasome and autophagy-lysosome pathways (DC50=0.315 µM). ZX703 induces ferroptosis by inducing Reactive Oxygen Species (ROS) accumulation in cells. ZX703 can be used for cancer research[1].
Molecular Weight:
1039.68
Formula:
C54H67ClN8O9S
Target:
Ferroptosis,Glutathione Peroxidase,PROTACs,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound1
* VAT and and shipping costs not included. Errors and price changes excepted
