Antimalarial agent 38 is an orally active antimalarial agent, which inhibits Plasmodium falciparum D6 strain, Chloroquine (HY-17589A)-sensitive Thai strain and Chloroquine-resistant FcB1 strain and K1 strain, with IC50s of 0.5, 13, 1 and 13 µM, respectively. Antimalarial agent 38 is non-cytotoxic for mammalian cells MCR58 (IC50 >140 µM). Antimalarial agent 38 improves the survival rate of Plasmodium yoelii nigeriensis infected mouse model[1].
Molecular Weight:
692.71
Purity:
99.55
CAS Number:
[123580-46-1]
Formula:
C36H40N2O12
Target:
Parasite
Application Notes:
MCE Product type: Reference compound
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