PKM2-IN-6 (compound 7d) is a potent and orally active PKM2 inhibitor with an IC50 value of 23 nM. PKM2-IN-6 induces apoptosis and cell cycle arrest at G2 phase. PKM2-IN-6 reduces the level of PKM1 and PKM2 at the mRNA level. PKM2-IN-6 shows anticancer activity and has the potential for the research of triple-negative breast cancer[1].
Molecular Weight:
322.38
Purity:
99.95
CAS Number:
[771467-00-6]
Formula:
C17H14N4OS
Target:
Apoptosis,Pyruvate Kinase
Application Notes:
MCE Product type: Reference compound1
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