Keap1-Nrf2-IN-18 (Compound 22) is an orally active Keap1-Nrf2 protein-protein interaction (PPI) inhibitor with good pharmacokinetics (PK) profiles and more potent in vivo activities in rats. Keap1-Nrf2-IN-18 has the strongest inhibitory activity in structure-activity relationship (SAR) study (KD = 0.0029 µM)[1].
Molecular Weight:
464.53
Formula:
C27H29FN2O4
Target:
Keap1-Nrf2
Application Notes:
MCE Product type: Reference compound1
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