Nemorubicin (Methoxymorpholinyl doxorubicin) is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity[1][2][3][4].
Molecular Weight:
643.64
Purity:
97.80
CAS Number:
[108852-90-0]
Formula:
C32H37NO13
Target:
G-quadruplex
Application Notes:
MCE Product type: Reference compound1
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