ART0380 is a potent, selective and orally active ATR kinase inhibitor. ART0380 potently inhibits human ATR-ATRIP complex with an IC50 of 51.7 nM. ART0380 binds the ATP pocket of the ATR-ATRIP complex, blocks ATR-dependent Chk1 serine 345 phosphorylation, and induces cell cycle disorder and DNA damage. ART0380 demonstrates potent and selective antitumor activity in preclinical models with varying types of ataxia-telangiectasia mutated (ATM) gene aberrancy. ART0380 can be used for the research of cancer, such as colorectal cancer and prostate cancer[1].
Molecular Weight:
388.49
Purity:
99.90
CAS Number:
[2267316-76-5]
Formula:
C18H24N6O2S
Target:
ATM/ATR,Checkpoint Kinase (Chk),DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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