Antiproliferative agent-49 (Compound 5a) is a EGFR-TK inhibitor with an IC50 of 0.09 µM. Antiproliferative agent-49 is a anti-proliferative agent. Antiproliferative agent-49 displays good activities against HER3 and HER4 with IC50 values 0.18 and 0.37 µM. Antiproliferative agent-49 induces mitochondrial apoptotic pathway and increased accumulation of ROS[1].
Molecular Weight:
374.46
Formula:
C22H18N2O2S
Target:
Apoptosis,EGFR
Application Notes:
MCE Product type: Reference compound
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