PROTAC PARP1 degrader-1 (Compound CN0) is a PROTAC degrader of PARP1. PROTAC PARP1 degrader-1 activates the cGAS/STING immunity pathway and eventually enhances T cell killing of tumor cells. PROTAC PARP1 degrader-1 inhibits DNA damage repair, resulting in highly efficient accumulation of cytosolic DNA fragments (Blue: CRBN ligand, Black: linker, Pink: PARP1 inhibitor)[1].
Molecular Weight:
576.60
Purity:
99.86
Formula:
C32H28N6O5
Target:
PARP,PROTACs
Application Notes:
MCE Product type: Reference compound
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