PXB17 can inhibit CSF1R (IC50 = 1.7 nM) by blocking the activation of PI3K/ AKT/mTORC1 signaling. PXB17 is orally effective. PXB17 significantly inhibits the growth of CRC, improves PD-1 mAb efficacy and reduces tumor recurrence in CRC[1].
Molecular Weight:
545.63
Formula:
C29H35N7O4
Target:
c-Fms
Application Notes:
MCE Product type: Reference compound
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