LC-1-40 is a PROTAC that selectively degrades NUDT1 (DC50=0.97 nM). LC-1-40 selectively inhibits MYCN-induced tumor growth in mouse models. LC-1-40 also induces nucleotide damage and apoptosis in MYCN-associated tumors. LC-1-40 can be used in cancer research[1]. (Red: NUDT1 binder, Blue: CRBN ligand, Black: Linker).
Molecular Weight:
844.96
Formula:
C49H48N8O6
Target:
Apoptosis,DNA/RNA Synthesis,PROTACs
Application Notes:
MCE Product type: Reference compound
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