NST-628 is a brain-permeable MAPK pathway molecule glue that inhibits RAF phosphorylation and MEK activation. NST-628 also binds RAF and prevents the formation of BRAF-CRAF and BRAF-ARAF heterodimers, effectively inhibiting the RAS-MAPK pathway. NST-628 inhibits RAS- and RAF-driven cancers and demonstrated potent inhibition in mutant KRAS, NRAS, BRAF class II/III, and NF1-mutant tumors[1].
Molecular Weight:
488.46
Purity:
98.61
CAS Number:
[3002056-30-3]
Formula:
C22H18F2N4O5S
Target:
MEK,Molecular Glues,Raf
Application Notes:
MCE Product type: Reference compound
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