HG-7-85-01 is a type II ATP competitive inhibitor of wild-type and gatekeeper mutations forms of Bcr-Abl, PDGFRalpha, Kit, and Src kinases. HG-7-85-01 inhibits T315I mutant Bcr-Abl kinase, KDR and RET with IC50s of 3 nM, 20 nM and 30 nM, and is only weak or no inhibition of other kinases (IC50>2 µM). HG-7-85-01 inhibits the cell proliferation, which is mediated by the induction of apoptosis, and inhibition of cell-cycle progression[1].
Molecular Weight:
608.68
Purity:
99.94
CAS Number:
[1258391-13-7]
Formula:
C31H31F3N6O2S
Target:
Apoptosis,Bcr-Abl,c-Kit,JAK,PDGFR,Src
Application Notes:
MCE Product type: Reference compound
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