MY-1B is a covalent inhibitor of the RNA Methyltransferase NSUN2 (IC50: 1.3 µM). MY-1B stereoselectively ligands active-site cysteine residues (C271) of NSUN2. MY-1B can stereoselectively and covalently bind to PSME1, disrupting the proteasome regulatory complex and downregulating the presentation of specific MHC-I subtypes[1][2][3].
Molecular Weight:
436.30
Purity:
99.94
CAS Number:
[2929308-79-0]
Formula:
C22H18BrN3O2
Target:
DNA Methyltransferase,RNA MTase
Application Notes:
MCE Product type: Reference compound
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