SOS1/EGFR-IN-1 (compound SE-9) is a dual-target inhibitor for the prostate cancer. SOS1/EGFR-IN-1 inhibits effectively SOS1(IC50=42.131.55 nM) and EGFR(IC50=1.010.04 nM) by inhibiting their downstream effector molecules. SOS1/EGFR-IN-1 induces apoptosis and G1 phase cell cycle arrest, reducing angiogenesis and migration. SOS1/EGFR-IN-1 shows significant antitumor effects in prostate cancer cells PC-3 (IC50=0.450.03 µM)[1].
Molecular Weight:
397.44
Purity:
99.54
CAS Number:
[2956724-20-0]
Formula:
C22H24FN3O3
Target:
EGFR,Ras,SOS1
Application Notes:
MCE Product type: Reference compound
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