IOX5 is a selective prolyl hydroxylase (PHD) inhibitor with an IC50 of 0.19 µM for PHD2. IOX5 stabilizes HIF-1alpha in acute myeloid leukemia (AML) cells, inhibits cell proliferation and induces apoptosis. IOX5 has anti-leukemia activity[1].
Molecular Weight:
368.35
Purity:
99.39
Formula:
C17H19F3N4O2
Target:
Apoptosis,HIF/HIF Prolyl-Hydroxylase
Application Notes:
MCE Product type: Reference compound
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