BIO-8169 is a selective inhibitor for interleukin receptor-associated kinase 4 (IRAK 4), with an IC50 of 0.23 nM. BIO-8169 exhibits good pharmacokinetic character, reduces the production of pro-inflammatory cytokines, and attenuates the autoimmune encephalomyelitis in EAE mice model. BIO-8169 exhibits good blood brain penetrant with a rat Kpu,u of 0.7[1].
Molecular Weight:
449.50
CAS Number:
[2792153-06-9]
Formula:
C24H27N5O4
Target:
IRAK
Application Notes:
MCE Product type: Reference compound
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