Pan-rasin-2 (compound 6A) is an orally active molecular glues that targets RAS. Pan-RAS-IN-2 inhibits pERK (IC50 in AsPC-1 cells: 0.3 nM). Pan-rasin-2 has significant inhibitory activity on cell proliferation of RAS mutant cell lines. Pan-rasin-2 can form ternary complexes with cyclophilin A (CYPA) and RAS (ON) proteins and the formation of ternary complexes can block the binding of RAF downstream of RAS, which has anti-tumor (such as colorectal cancer, pancreatic cancer) effects[1].
Molecular Weight:
837.08
Purity:
98.00
CAS Number:
[3034673-92-9]
Formula:
C46H60N8O5S
Target:
Cyclophilin,Molecular Glues,PERK,Ras
Application Notes:
MCE Product type: Reference compound
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