YX-02-030M is a PROTAC MDM2 degrader. YX-02-030M inhibits MDM2-p53 binding and VHL-HIF1alpha binding with IC50s of 63 nM and 1.35 µM respectively. YX-02-030M binds MDM2 and recruits the VHL E3 ubiquitin ligase to initiate MDM2 degradation, and effectively kills p53 mutant or deleted Triple-negative breast cancers (TNBC) cells[1].
Molecular Weight:
1267.41
Purity:
99.86
CAS Number:
[3049076-98-1]
Formula:
C66H85Cl2N9O10S
Target:
MDM-2/p53,PROTACs
Application Notes:
MCE Product type: Reference compound1
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