RG7112D is a potent MDM2 inhibitor with IC50s of 11 nM and >10000 nM and for MDM2-p53 and VHL-HIF1alpha by binding HTRF assay, respectively. RG7112D is coupled by an amide bond to VHL-Amine, resulting in a bi-functional molecule, YX-02-030. YX-02-03, a MDM2-PROTAC, potently inhibits MDM2-p53 binding (HTRF IC50=63nM). RG7112D can stabilize MDM2 protein and increase p53 protein levels[1].
Molecular Weight:
665.65
CAS Number:
[2360561-90-4]
Formula:
C36H42Cl2N4O4
Target:
MDM-2/p53
Application Notes:
MCE Product type: Reference compound1
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