GNE-783 is a selective CHK1 inhibitor that enhances the activity of gemcitabine. GNE-783 improves the efficacy of anti-metabolite DNA damage drugs by inactivating S-phase and G2-phase cell cycle checkpoints following DNA damage. GNE-783 selectively enhances the chemical synergy of certain drugs in different tumor types, for example, enhancing the activity of temozolomide only in melanoma cell lines[1].
Molecular Weight:
368.43
CAS Number:
[1200127-66-7]
Formula:
C22H20N6
Target:
Endogenous Metabolite
Application Notes:
MCE Product type: Reference compound
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