ISTH0036 is a phosphorothioate LNA-modified antisense oligonucleotide gapmer that selectively targets and downregulates TGF-beta2 mRNA. ISTH0036 suppresses TGF-beta2 expression, reduces choroidal neovascularization and vascular leakage, inhibits fibrosis, blocks epithelial-to-mesenchymal transition, and inhibits angiogenesis while promoting bleb survival. ISTH0036 exhibits long-lasting, dose-dependent ocular tissue distribution and target engagement in rabbit and non-human primate eyes. ISTH0036 can be used for the study of various ocular disorders, such as glaucoma and neovascular retinal diseases[1][2][3].
Purity:
96.85
CAS Number:
[2179222-27-4]
Target:
TGF-beta/Smad
Application Notes:
MCE Product type: Oligonucleotides
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